EDIT: Issue resolved. I had to open the ports via the Plesk firewall.
I moved my node-application from my local Debian-VM to a CentOS-Server, where it also will be running in production one day.
There is the react-frontend part. Which is for development running through the react-scripts to start on port 3000 via npm start.
Then there is the backend which is just an api for fetching data and stuff, built with express.
Problem: Although starting these up throws no error at all, I can't access them through the browser or postman.
On my local VM it was just localhost + :port, but now I have an domain and I think there is the error that I don't see nor understand.
Hope someone can shed some light here. :)