Thanks to Craig answer, I found the solution. I will post both code ( client and server ) to help in case of future use. The CLient server is uploading file and Json in the "form" feature of flask. Then some ast and some dict to make the Payload clearer ( I know this is ugly way, but this is the best scholar approach )
On Client side : 
datas = {'CurrentMail': "AA", 'STRUserUUID1': "BB", 'FirstName': "ZZ",     'LastName': "ZZ",  'EE': "RR", 'JobRole': "TT"  }
#sending user infos to app server using python "requests"
url = "http://10.100.2.6:80/customerupdate"
def send_request():
    payload = datas
    local_file_to_send = 'user_picture.jpg' 
    files = {
     'json': (None, json.dumps(payload), 'application/json'),
     'file': (os.path.basename(local_file_to_send), open(local_file_to_send, 'rb'), 'application/octet-stream')
    }
    r = requests.post(url, files=files)
send_request()
On Flask Server side :
import sys, os, logging, time, datetime, json, uuid, requests, ast
from flask import Flask, request , render_template
from werkzeug import secure_filename
from werkzeug.datastructures import ImmutableMultiDict
from flask_restful import Resource, Api
app = Flask(__name__)
api = Api(app)
app.debug = True
class OPERATIONS(Resource):
        @app.route('/',methods=['GET'])
        def hello_world():
            return 'Hello World!'
        @app.route('/customerupdate',methods=['GET','POST'])
        def customerupdate():
            print "************DEBUG 1 ***********"
            RequestValues = request.values
            print RequestValues
            print "************DEBUG 2 ***********"
            RequestForm = request.form
            print RequestForm
            print "************DEBUG 2-1 ***********"
            so = RequestForm
            json_of_metadatas = so.to_dict(flat=False)
            print json_of_metadatas
            print "************DEBUG 2-2 ***********"
            MetdatasFromJSON = json_of_metadatas['json']
            print MetdatasFromJSON          
            print "************DEBUG 2-3 ***********"
            MetdatasFromJSON0 = MetdatasFromJSON[0]
            print MetdatasFromJSON0
            print "************DEBUG 3-5 ***********"
            strMetdatasFromJSON0 = str(MetdatasFromJSON0)
            MetdatasDICT = ast.literal_eval(strMetdatasFromJSON0)
            print MetdatasDICT
            print "************DEBUG 3-5 ***********"
            for key in MetdatasDICT :
                print "key: %s , value: %s" % (key, MetdatasDICT[key])
            print "************DEBUG 4 ***********"
            f = request.files['file']
            f.save(secure_filename(f.filename))
            print "FILE SAVED LOCALY"
            return 'JSON of customer posted'