I had read something like that in another question. Based on this tutorial:  I found the answer to all my problems. 
this tutorial explain how to use a PJAX library that manages both the client and server side.
Thanks to 3 rows of code you can obtain a speed navigation without reload the page. 
- Install client side library from jQuery-pjax page
- into your html page that send the request add: <a href='/yourLink' data-pjax='main'>YourLink</a>
where main is the div that will content yout change. In my case is: 
 <div id="main" class="main">                    
       {{{body}}}                    
 </div>
- In your.js file add  - $('a[data-pjax]').pjax();This command 'simply call the pjax extension on every element that contains the data attribute ‘data-pjax’'
 
- Install inside express the depency with the command: - npm install --save express-pjax
 
- Set your server:  - var app = express();
var pjax = require('express-pjax');
...
app.use(pjax())
 
- Replace the normal rendering: 
res.render('index', {title: "Index"});
with
res.renderPjax('index', {title: "Index"});
UPDATE
Alternatively you can obtain the same result. Consider that the structure of the project is as follows: 
views
  |-> partials
  |      |-> addtest.hbs
  |
  |-> index.hbs
For example, image that in your index.hbs you have a sidebar with different items, described in this way: 
<li>
    <a href="#testDB" data-toggle="collapse" aria-expanded="false" class="dropdown-toggle">
   <img src="../img/database-data.svg" class="svg icon">Test</a>
    <ul class="collapse list-unstyled select-specific" id="testDB">
        <li value="addTest" class=" ">
            <a href="#" id="add-new-test">Add Test</a>
        </li>
         ....
         ....
    </ul>
 </li>
Inside the partials directory you have a simply form. 
Now for manage the form you have to do two operations: 
- Server side: For switching from one partial to another without refresh the page, you specify:  - router.get('/addtest', function (req, res) {
    res.status(200);
    res.header("Content-Type", "text/html");
    res.render('partials/addtest', {title: "Add Test"});
}); 
- Client side: In your client side file, you add make a simple get request:  - $('#add-new-test').click(function (event) {
    $.get('/addtest').then(function (data) {
      $('#main').html(data);
    });
  }); 
In this way, when you make a get request with the same address (i.e in this case /addtest) the client add a part of code inside your view without refresh all. 
NOTE: Keep in mind that, if you needed a some file.js in your partial, for load the file, use this: 
<script>
var url = "/scripts/script.js";
$.getScript(url);
</script>
This is used for avoid: “Synchronous XMLHttpRequest on the main thread is deprecated…” because the call is asynchronous. For more info..