I was trying to apply this to my fbs based app and found the below easily allowed me to style the app by applying it to the AppContext
class AppContext(ApplicationContext):
    def run(self):
        self.main_window.show()
        return self.app.exec_()
    @cached_property
    def main_window(self):
        return MainWindow(self)
    if theme_selection == 'Dark':
        QApplication.setStyle("Fusion")
        #
        # # Now use a palette to switch to dark colors:
        dark_palette = QPalette()
        dark_palette.setColor(QPalette.Window, QColor(53, 53, 53))
        dark_palette.setColor(QPalette.WindowText, Qt.white)
        dark_palette.setColor(QPalette.Base, QColor(35, 35, 35))
        dark_palette.setColor(QPalette.AlternateBase, QColor(53, 53, 53))
        dark_palette.setColor(QPalette.ToolTipBase, QColor(25, 25, 25))
        dark_palette.setColor(QPalette.ToolTipText, Qt.white)
        dark_palette.setColor(QPalette.Text, Qt.white)
        dark_palette.setColor(QPalette.Button, QColor(53, 53, 53))
        dark_palette.setColor(QPalette.ButtonText, Qt.white)
        dark_palette.setColor(QPalette.BrightText, Qt.red)
        dark_palette.setColor(QPalette.Link, QColor(42, 130, 218))
        dark_palette.setColor(QPalette.Highlight, QColor(42, 130, 218))
        dark_palette.setColor(QPalette.HighlightedText, QColor(35, 35, 35))
        dark_palette.setColor(QPalette.Active, QPalette.Button, QColor(53, 53, 53))
        dark_palette.setColor(QPalette.Disabled, QPalette.ButtonText, Qt.darkGray)
        dark_palette.setColor(QPalette.Disabled, QPalette.WindowText, Qt.darkGray)
        dark_palette.setColor(QPalette.Disabled, QPalette.Text, Qt.darkGray)
        dark_palette.setColor(QPalette.Disabled, QPalette.Light, QColor(53, 53, 53))
        QApplication.setPalette(dark_palette)
    elif theme_selection == 'Light':
        QApplication.setStyle("")
        pass
    else:
        pass
You can use Qsettings to save a preference for which mode like this and restore on start.
if settings.contains("theme_selection"):
    # there is the key in QSettings
    print('Checking for theme preference in config')
    theme_selection = settings.value('theme_selection')
    print('Found theme_selection in config:' + theme_selection)
else:
    if not is_mac():
        print('theme_selection not found in config. Using default Darkmode')
        settings.setValue('theme_selection', 'Dark')
        theme_selection = settings.value('theme_selection')
    elif is_mac():
        print('theme_selection not found in config. Using default Lightmode')
        settings.setValue('theme_selection', 'Light')
        theme_selection = settings.value('theme_selection')
    pass
Looks amazing could not comment on Michael Herrmann's post to say thanks but did upvote it.
Before:

After:

Middle part is xterm.js so that is why its still white for now as its not a QT styled thing.