Not sure I'm getting your question exactly, and I don't know whether clion gives you access to the lldb script interpreter, but given this example:
struct Foo
{
  int a;
  int b;
  int c;
};
void ChangeFoo(struct Foo *input)
{
  input->a += 10;
}
int
main()
{
  struct Foo my_foo = {10, 20, 30};
  ChangeFoo(&my_foo);
  return 0;
}
from command-line lldb you can do:
(lldb) br s -l 17
Breakpoint 1: where = tryme`main + 39 at tryme.c:17, address = 0x0000000100000f97
(lldb) br s -l 18
Breakpoint 2: where = tryme`main + 46 at tryme.c:18, address = 0x0000000100000f9e
(lldb) run
Process 16017 launched: '/tmp/tryme' (x86_64)
Process 16017 stopped
* thread #1, queue = 'com.apple.main-thread', stop reason = breakpoint 1.1
    frame #0: 0x0000000100000f97 tryme`main at tryme.c:17
   14   main()
   15   {
   16     struct Foo my_foo = {10, 20, 30};
-> 17     ChangeFoo(&my_foo);
          ^
   18     return 0;
   19   }
Target 0: (tryme) stopped.
(lldb) script value = lldb.frame.FindVariable("my_foo")
(lldb) script print value
(Foo) my_foo = {
  a = 10
  b = 20
  c = 30
}
(lldb) n
Process 16017 stopped
* thread #1, queue = 'com.apple.main-thread', stop reason = breakpoint 2.1
    frame #0: 0x0000000100000f9e tryme`main at tryme.c:18
   15   {
   16     struct Foo my_foo = {10, 20, 30};
   17     ChangeFoo(&my_foo);
-> 18     return 0;
          ^
   19   }
Target 0: (tryme) stopped.
(lldb) script
Python Interactive Interpreter. To exit, type 'quit()', 'exit()' or Ctrl-D.
>>> for i in range(0,value.GetNumChildren()):
...     print(i, " ", value.GetChildAtIndex(i).GetValueDidChange())
... 
(0, ' ', True)
(1, ' ', False)
(2, ' ', False)
>>> print value.GetChildAtIndex(0)
(int) a = 20
Note, if my_foo above had been a pointer, we would have only fetched the pointer value which isn't what you want to compare.  In that case, when you capture the value do:
(lldb) script value = lldb.frame.FindVariable("my_foo_ptr").Dereference()
where you get the value originally, and then everything after will go as above.