As discussed in the comments on this answer, setting certain values can have unexpected consequences.
In Javascript, this is more likely because setting a global variable actually means setting a property of the window object. For instance:
function foo (input) {
top = 45;
return top * input;
}
foo(5);
This returns NaN because you can't set window.top and multiplying a window object doesn't work. Changing it to var top = 45 works.
Other values that you can't change include document. Furthermore, there are other global variables that, when set, do exciting things. For instance, setting window.status updates the browser's status bar value and window.location goes to a new location.
Finally, if you update some values, you may lose some functionality. If, for instance, you set window.frames to a string, for instance, you can't use window.frames[0] to access a frame.