I've successfully deployed the following contract on Kaleido:
pragma solidity ^0.4.0;
contract Greeter {
    string public greeting;
    function Greeter() {
        greeting = 'Hello';
    }
    function setGreeting(string _greeting) public {
        greeting = _greeting;
    }
    function greet() constant returns (string) {
        return greeting;
    }
}
I try to interact with the contract like so:
from web3 import Web3
from web3.providers import HTTPProvider
from solc import compile_source
from web3.contract import ConciseContract
# Solidity source code
contract_source_code = '''
pragma solidity ^0.4.0;
contract Greeter {
    string public greeting;
    function Greeter() {
        greeting = 'Hello';
    }
    function setGreeting(string _greeting) public {
        greeting = _greeting;
    }
    function greet() constant returns (string) {
        return greeting;
    }
}
'''
compiled_sol = compile_source(contract_source_code) 
contract_interface = compiled_sol[':Greeter']
w3 = Web3(HTTPProvider("https://user:password@u0telyzine-u0od4ny83j-rpc.us-east-2.kaleido.io"))
# address from previous deployment
contract_address = Web3.toChecksumAddress("0x4c94e89d5ec3125339906109f143673f40868df2")
greeter = w3.eth.contract(
    address=contract_address,
    abi=contract_interface['abi'],
)
print('Default contract greeting: {}'.format(
    greeter.functions.greet().call()
))
# --- this hangs ---
print('Setting the greeting to Nihao...')
tx_hash = greeter.functions.setGreeting('Nihao').transact({ 'from': w3.eth.accounts[0], 'gas': 100000})
w3.eth.waitForTransactionReceipt(tx_hash)
print('Updated contract greeting: {}'.format(
    greeter.functions.greet().call()
))
reader = ConciseContract(greeter)
assert reader.greet() == "Nihao"
However, when I try to submit a transaction which calls setGreeting the transaction hangs. Viewing the Kaleido logs, I see VM in read-only mode. Mutating opcode prohibited. Also, when I visit the block explorer for my node, the transactions don't load while the blocks do. 
What can I do about this read only mode?
