Basically, build an array of your test values, and loop that array until you find something.
Something like this
Sub Demo()
    Dim ws As Worksheet
    Dim rTestStings As Range, TestStings As Variant
    Dim TestValue As Variant
    Dim idx As Long
    Dim Found As Boolean
    'Get Test Strings from Sheet.  Adjust to suit your data
    With rTestStings = Worksheets("specific sheet")
        Set rTestStings = .Range(.Cells(1, 1), .Cells(.Rows.Count, 1).End(xlUp))
    End With
    TestStings = rTestStings.Value2
    Set ws = Sheets("Le 2250")
    'I'm guessing you are doing something like this
    For i = SomeValue To SomeOtherValue
        TestValue = ws.Cells(i, 1).Value
        Found = False
        For idx = LBound(TestStings, 1) To UBound(TestStings, 1)
            If Not IsEmpty(TestStings(idx, 1)) Then  'incase there are gaps in your test data
                If InStr(TestValue, TestStings(idx, 1)) Then
                    Found = True
                    Exit For
                End If
            End If
        Next
        If Found Then
            MsgBox "Found " & TestStings(idx, 1) & " in cell " & ws.Cells(i, 1).Address
            ' do something ...
        End If
    Next i
End Sub