You can create objects using the new keyword in a spring application.
But these objects would be outside the scope of the Spring Application Context and hence are not spring managed.
Since these are not spring managed, any nested levels of dependency (such as your Service class having a reference to your Repository class etc)
will not be resolved.
So if you try to invoke a method in your service class, you might end up getting a NullPointer for the repository.
@Service
public class GreetingService {
    @Autowired
    private GreetingRepository greetingRepository;
    public String greet(String userid) {
       return greetingRepository.greet(userid); 
    }
}
@RestController
public class GreetingController {
    @Autowired
    private GreetingService greetingService;
    @RequestMapping("/greeting")
    public String greeting(@RequestParam(value = "name", defaultValue = "World") String name) {
        return String.format("Hello %s", greetingService.greet(name));
    }
    @RequestMapping("/greeting2")
    public String greeting2(@RequestParam(value = "name", defaultValue = "World") String name) {
      GreetingService newGreetingService = new GreetingService();
      return String.format("Hello %s", newGreetingService.greet(name));
    }
}
In the above example /greeting will work but /greeting2 will fail because the nested dependencies are not resolved.
So if you want your object to be spring managed, then you have to Autowire them. 
Generally speaking, for view layer pojos and custom bean configurations, you will use the new keyword.