How can you create an if else statement in python when you have a file with both text and numbers. 
 Let's say I want to replace the values from the third to last column in the file below. I want to create an if else statement to replace values <5 or if there's a dot "."  with a zero, and if possible to use that value as integer for a sum.
A quick and dirty solution using awk would look like this, but I'm curious on how to handle this type of data with python: 
 awk -F"[ :]" '{if ( (!/^#/) && ($9<5 || $9==".") ) $9="0" ; print }'
So how do you solve this problem?
Thanks
Input file:
\##Comment1
\#Header
sample1 1   2   3   4   1:0:2:1:.:3
sample2 1   4   3   5   1:3:2:.:3:3
sample3 2   4   6   7   .:0:6:5:4:0
Desired output: 
\##Comment1
\#Header
sample1 1   2   3   4   1:0:2:0:0:3
sample2 1   4   3   5   1:3:2:0:3:3
sample3 2   4   6   7   .:0:6:5:4:0
SUM = 5
Result so far 
['sample1', '1', '2', '3', '4', '1', '0', '2', '0', '0', '3\n']
['sample2', '1', '4', '3', '5', '1', '3', '2', '0', '3', '3\n']
['sample3', '2', '4', '6', '7', '.', '0', '6', '5', '4', '0']
Here's what I have tried so far:
import re
data=open("inputfile.txt", 'r')
for line in data:
    if not line.startswith("#"):
        nodots = line.replace(":.",":0") 
        final_nodots=re.split('\t|:',nodots)
        if (int(final_nodots[8]))<5:
            final_nodots[8]="0"
            print (final_nodots)
        else:
            print(final_nodots)
 
    