What you can do is, first open the file, then read all the lines into a list content removing \n from each as you do so. From here you can search this list for your target which has the word or some unique phrase in it, for this we used password. No we can set that to target while splitting it at the =, and also store the target_idx. From here we just alter the second index of target that we .split('=') and then .join() that back together. Now we can assign our new line phrase to the target_idx of content replacing the old target. After we can open our text.txt back up and write the new content using '\n'.join(content)
with open('text.txt') as f:
content = [line.strip() for line in f]
for i in content:
if 'password' in i:
target = i.split('=')
target_idx = content.index(i)
target[-1] = 'My_Password'
mod = '='.join(target)
content[target_idx] = mod
with open('text1.txt', 'w') as f:
f.write('\n'.join(content))
Before
chrx@chrx:~/python/stackoverflow/10.3$ cat text.txt
some line
some line
some line
min.pop.password=SomeRandomNumbersWordsCharacters
some line
some line
some line
After
chrx@chrx:~/python/stackoverflow/10.3$ cat text.txt
some line
some line
some line
min.pop.password=My_Password
some line
some line
some line