I'm struggling to figure out how to remove rows from a pandas dataframe in which two specified columns have the same value across a row.
For example, in the below examples I would like to remove the rows which have duplicate values in the columns 2 and 4.
For example:
Column1 Column2 Column3 Column4
  Pat     123     John    456
  Pat     123     John    345 
  Jimmy   678     Mary    678 
  Larry   678     James   983
Would turn into:
Column1 Column2 Column3 Column4
  Pat     123     John    456 
  Pat     123     John    345
  Larry   678     James   983
Any help is appreciated, thank you!
 
     
    