your best bet is to use regular expressions.
strings are immutable meaning that you can't change them - you need to rewrite the whole string - to do it in optimal way you should use StringBuilder class and Append every character that you want.
Also watch out for your code - char.IsNumber checks not only for characters 0-9, it also returns true for every numeric character such as ٢ and you probably don't want that.
here's the full list of characters returning true:
0123456789٠١٢٣٤٥٦٧٨٩۰۱۲۳۴۵۶۷۸۹߀߁߂߃߄߅߆߇߈߉०१२३४५६७८९০১২৩৪৫৬৭৮৯੦੧੨੩੪੫੬੭੮੯૦૧૨૩૪૫૬૭૮૯୦୧୨୩୪୫୬୭୮୯௦௧௨௩௪௫௬௭௮௯౦౧౨౩౪౫౬౭౮౯೦೧೨೩೪೫೬೭೮೯൦൧൨൩൪൫൬൭൮൯๐๑๒๓๔๕๖๗๘๙໐໑໒໓໔໕໖໗໘໙༠༡༢༣༤༥༦༧༨༩၀၁၂၃၄၅၆၇၈၉႐႑႒႓႔႕႖႗႘႙០១២៣៤៥៦៧៨៩᠐᠑᠒᠓᠔᠕᠖᠗᠘᠙᥆᥇᥈᥉᥊᥋᥌᥍᥎᥏᧐᧑᧒᧓᧔᧕᧖᧗᧘᧙᭐᭑᭒᭓᭔᭕᭖᭗᭘᭙᮰᮱᮲᮳᮴᮵᮶᮷᮸᮹᱀᱁᱂᱃᱄᱅᱆᱇᱈᱉᱐᱑᱒᱓᱔᱕᱖᱗᱘᱙꘠꘡꘢꘣꘤꘥꘦꘧꘨꘩꣐꣑꣒꣓꣔꣕꣖꣗꣘꣙꤀꤁꤂꤃꤄꤅꤆꤇꤈꤉꩐꩑꩒꩓꩔꩕꩖꩗꩘꩙0123456789
you should also use [0-9] rather than \d in your regular expressions if you want only parsable digits.
You can also use a trick to .Split your string on your character, then .Join it back. This not only allows you to remove one or more characters, it also lets you to replace it with some other character.
I use this trick to remove incorrect characters from file name:
string.Join("-", possiblyIncorrectFileName.Split(Path.GetInvalidFileNameChars()))
this code will replace any character that cannot be used in valid file name to -