Just for fun I'm trying to draw on 3D transformed canvases. I wrote some code and it kind of works
const m4 = twgl.m4;
[...document.querySelectorAll('canvas')].forEach((canvas) => {
  const ctx = canvas.getContext('2d');
  let count = 0;
  canvas.addEventListener('mousemove', (e) => {
    const pos = getElementRelativeMousePosition(e, canvas);
    ctx.fillStyle = hsl((count++ % 10) / 10, 1, 0.5);
    ctx.fillRect(pos.x - 1, pos.y - 1, 3, 3);
  });
});
function getElementRelativeMousePosition(e, elem) {
  const pos = convertPointFromPageToNode(elem, e.pageX, e.pageY); 
  
  return {
    x: pos[0],
    y: pos[1],
  };
}
function hsl(h, s, l) {
  return `hsl(${h * 360 | 0},${s * 100 | 0}%,${l * 100 | 0}%)`;
}
function convertPointFromPageToNode(elem, pageX, pageY) {
  const mat = m4.inverse(getTransformationMatrix(elem));
  return m4.transformPoint(mat, [pageX, pageY, 0]);
};
function getTransformationMatrix(elem) {
  let matrix = m4.identity();
  let currentElem = elem;
  while (currentElem !== undefined && 
         currentElem !== currentElem.ownerDocument.documentElement) {
    const style = window.getComputedStyle(currentElem);
    const localMatrix = parseMatrix(style.transform);
    matrix = m4.multiply(localMatrix, matrix);
    currentElem = currentElem.parentElement;
  }
  const w = elem.offsetWidth;
  const h = elem.offsetHeight;
  let i = 4;
  let left = +Infinity;
  let top = +Infinity;
  for (let i = 0; i < 4; ++i) {
    const p = m4.transformPoint(matrix, [w * (i & 1), h * ((i & 2) >> 1), 0]);
    left = Math.min(p[0], left);
    top = Math.min(p[1], top);
  }
  const rect = elem.getBoundingClientRect()
  document.querySelector('p').textContent =
    `${w}x${h}`;
  matrix =  m4.multiply(m4.translation([
     window.pageXOffset + rect.left - left, 
     window.pageYOffset + rect.top - top,
     0]), matrix);
  return matrix;
}
function parseMatrix(str) {
  if (str.startsWith('matrix3d(')) {
    return str.substring(9, str.length - 1).split(',').map(v => parseFloat(v.trim()));
  } else if (str.startsWith('matrix(')) {
    const m = str.substring(7, str.length - 1).split(',').map(v => parseFloat(v.trim()));
    return [
      m[0], m[1], 0, 0,
      m[2], m[3], 0, 0,
      0, 0, 1, 0,
      m[4], m[5], 0, 1,
    ]
  } else if (str == 'none') {
    return m4.identity();
  }
  throw new Error('unknown format');
}
canvas { 
  display: block;
  background: yellow;
  transform: scale(0.75);
}
#c1 {
  margin: 20px;
  background: red;
  transform: translateX(-50px);
  display: inline-block;
}
#c2 {
  margin: 20px;
  background: green;
  transform: rotate(45deg);
  display: inline-block;
}
#c3 {
  margin: 20px;
  background: blue;
  display: inline-block;
}
#c4 {
  position: absolute;
  top: 0;
  background: cyan;
  transform: translateX(-250px) rotate(55deg);
  display: inline-block;
}
#c5 {
  background: magenta;
  transform: translate(50px);
  display: inline-block;
}
#c6 {
  background: pink;
  transform: rotate(45deg);
  display: inline-block;
}
<p>
foo
</p>
<div id="c1">
  <div id="c2">
    <div id="c3">
      <canvas></canvas>
    </div>
  </div>
</div>
<div id="c4">
  <div id="c5">
    <div id="c6">
      <canvas></canvas>
    </div>
  </div>
</div>
<script src="https://twgljs.org/dist/4.x/twgl-full.min.js"></script>
The code above works. Move the mouse over either of the yellow canvas elements and you'll see it draws correctly.
But, as soon as I add some 3D transform it fails.
Change the CSS for '#c6' to
    #c6 {
      background: pink;
      transform: rotate(45deg) rotateX(45deg);  /* changed */
      display: inline-block;
    }
and now when I draw over the right yellow canvas things are off.
const m4 = twgl.m4;
[...document.querySelectorAll('canvas')].forEach((canvas) => {
  const ctx = canvas.getContext('2d');
  let count = 0;
  canvas.addEventListener('mousemove', (e) => {
    const pos = getElementRelativeMousePosition(e, canvas);
    ctx.fillStyle = hsl((count++ % 10) / 10, 1, 0.5);
    ctx.fillRect(pos.x - 1, pos.y - 1, 3, 3);
  });
});
function getElementRelativeMousePosition(e, elem) {
  const pos = convertPointFromPageToNode(elem, e.pageX, e.pageY); 
  
  return {
    x: pos[0],
    y: pos[1],
  };
}
function hsl(h, s, l) {
  return `hsl(${h * 360 | 0},${s * 100 | 0}%,${l * 100 | 0}%)`;
}
function convertPointFromPageToNode(elem, pageX, pageY) {
  const mat = m4.inverse(getTransformationMatrix(elem));
  return m4.transformPoint(mat, [pageX, pageY, 0]);
};
function getTransformationMatrix(elem) {
  let matrix = m4.identity();
  let currentElem = elem;
  while (currentElem !== undefined && 
         currentElem !== currentElem.ownerDocument.documentElement) {
    const style = window.getComputedStyle(currentElem);
    const localMatrix = parseMatrix(style.transform);
    matrix = m4.multiply(localMatrix, matrix);
    currentElem = currentElem.parentElement;
  }
  const w = elem.offsetWidth;
  const h = elem.offsetHeight;
  let i = 4;
  let left = +Infinity;
  let top = +Infinity;
  for (let i = 0; i < 4; ++i) {
    const p = m4.transformPoint(matrix, [w * (i & 1), h * ((i & 2) >> 1), 0]);
    left = Math.min(p[0], left);
    top = Math.min(p[1], top);
  }
  const rect = elem.getBoundingClientRect()
  document.querySelector('p').textContent =
    `${w}x${h}`;
  matrix =  m4.multiply(m4.translation([
     window.pageXOffset + rect.left - left, 
     window.pageYOffset + rect.top - top,
     0]), matrix);
  return matrix;
}
function parseMatrix(str) {
  if (str.startsWith('matrix3d(')) {
    return str.substring(9, str.length - 1).split(',').map(v => parseFloat(v.trim()));
  } else if (str.startsWith('matrix(')) {
    const m = str.substring(7, str.length - 1).split(',').map(v => parseFloat(v.trim()));
    return [
      m[0], m[1], 0, 0,
      m[2], m[3], 0, 0,
      0, 0, 1, 0,
      m[4], m[5], 0, 1,
    ]
  } else if (str == 'none') {
    return m4.identity();
  }
  throw new Error('unknown format');
}
canvas { 
  display: block;
  background: yellow;
  transform: scale(0.75);
}
#c1 {
  margin: 20px;
  background: red;
  transform: translateX(-50px);
  display: inline-block;
}
#c2 {
  margin: 20px;
  background: green;
  transform: rotate(45deg);
  display: inline-block;
}
#c3 {
  margin: 20px;
  background: blue;
  display: inline-block;
}
#c4 {
  position: absolute;
  top: 0;
  background: cyan;
  transform: translateX(-250px) rotate(55deg);
  display: inline-block;
}
#c5 {
  background: magenta;
  transform: translate(50px);
  display: inline-block;
}
#c6 {
  background: pink;
  transform: rotate(45deg) rotateX(45deg);
  display: inline-block;
}
<p>
foo
</p>
<div id="c1">
  <div id="c2">
    <div id="c3">
      <canvas></canvas>
    </div>
  </div>
</div>
<div id="c4">
  <div id="c5">
    <div id="c6">
      <canvas></canvas>
    </div>
  </div>
</div>
<script src="https://twgljs.org/dist/4.x/twgl-full.min.js"></script>
Any ideas what I'm doing wrong?