Keep your sql been readable with a help of verbatim strings and string interpolation and many an error will be evident. Here you should either wrap Safety = ... or Safety = ... in parenthesis (Safety = ... or Safety = ... ) or use in construction Safety in (...). 
Quick but dirty amendment is
...
string sql = $@"select * 
                  from Makerinfo 
                 where [Equipment Type] = '{equipmenttype_combobox.Text.Trim()}' 
                   and [Plant]          = '{plant_combobox.Text.Trim()}'
                   and [Safety]       in ('{firstsafety_textbox.Text.Trim()}', 
                                          '{secondsafety_textbox.Text.Trim()}', 
                                          '{thirdsafety_textbox.Text.Trim()}')";
SqlDataAdapter Data = new SqlDataAdapter(sql, sqlcon1);
...
However, this implementation has at least 3 flaws:
- It's prone to SQL Injection
- It will crash on equipmenttype_combobox.Text = "Browns' equipment"(note apostroph)
- For different plants, you have different queries which should be parsed, optimized etc. 
Much better aproach is parametrized query:
...
string sql = $@"select * 
                  from Makerinfo 
                 where [Equipment Type] = @prm_Equipment 
                   and [Plant]          = @prm_Plant
                   and [Safety]       in (@prm_Safety_1, @prm_Safety_2, @prm_Safety_3)";
using (SqlCommand q = new SqlCommand(sql, sqlcon1)) {
  // I don't know the underlying RDMBS types, that's why I've put AddWithValue
  //TODO: change AddWithValue to Add and provide the right rdbms type 
  // Something (and most probably) like
  //  q.Parameters.Add("@prm_Equipment", SqlDbType.VarChar).Value = 
  //    plant_combobox.Text.Trim();
  q.Parameters.AddWithValue("@prm_Equipment", equipmenttype_combobox.Text.Trim());
  q.Parameters.AddWithValue("@prm_Plant",     plant_combobox.Text.Trim());
  q.Parameters.AddWithValue("@prm_Safety_1",  firstsafety_textbox.Text.Trim());
  q.Parameters.AddWithValue("@prm_Safety_2",  secondsafety_textbox.Text.Trim());
  q.Parameters.AddWithValue("@prm_Safety_3",  thirdsafety_textbox.Text.Trim());  
  using (var reader = q.ExecuteReader()) {
    DataTable dt1 = new DataTable();
    dt1.Load(reader);
    datagridview1.DataSource = dt1;
  }
}
...