I had an issue with auto-layout, after enabling multi-line the result was like this:

so the titleLabel size doesn't affect the button size
I've added Constraints based on contentEdgeInsets (in this case contentEdgeInsets was (10, 10, 10, 10)
after calling makeMultiLineSupport():

hope it helps you (swift 5.0):   
extension UIButton {
    func makeMultiLineSupport() {
        guard let titleLabel = titleLabel else {
            return
        }
        titleLabel.numberOfLines = 0
        titleLabel.setContentHuggingPriority(.required, for: .vertical)
        titleLabel.setContentHuggingPriority(.required, for: .horizontal)
        addConstraints([
            .init(item: titleLabel,
                  attribute: .top,
                  relatedBy: .greaterThanOrEqual,
                  toItem: self,
                  attribute: .top,
                  multiplier: 1.0,
                  constant: contentEdgeInsets.top),
            .init(item: titleLabel,
                  attribute: .bottom,
                  relatedBy: .greaterThanOrEqual,
                  toItem: self,
                  attribute: .bottom,
                  multiplier: 1.0,
                  constant: contentEdgeInsets.bottom),
            .init(item: titleLabel,
                  attribute: .left,
                  relatedBy: .greaterThanOrEqual,
                  toItem: self,
                  attribute: .left,
                  multiplier: 1.0,
                  constant: contentEdgeInsets.left),
            .init(item: titleLabel,
                  attribute: .right,
                  relatedBy: .greaterThanOrEqual,
                  toItem: self,
                  attribute: .right,
                  multiplier: 1.0,
                  constant: contentEdgeInsets.right)
            ])
    }
}