I am using Msys2 portable under Win 10. I have 2 python 3.8 installations. The original question asked if that is so. I am now certain it is, so for the time being I want to deal with their maintenance.
I also posted another related question Msys2: readline in two python installations
I am posting below information on both.
My questions are:
- Can they interfere with each other? If so, what steps/configuration should I deal with? ( - PYTHONPATH,- site-packages, etc.)
- Would it be safe removing any one of them, without breaking the other? Dependencies below seem to me this implies no risk, but I am not certain that is enough information to answer this. 
- Which would be the best one to keep? I mean to use - numpy,- pandas, gcc-toolchain and debugger via Eclipse CDT, and a number of other packages.
PS1: This is in addition to python2, for which the same questions would apply.
PS2: It seems strange to me that the available subversions are not exactly the same, even if versions are both 3.8.2.
PS3:
These two pythons are likely upgrades from the main characters of this "play", python 3.8 (3.8.1 before) upgraded to mingw-w64-x86_64-python 3.8.2-2 and python 3.7 upgraded to python 3.8.2-1.
Packages providing python
$ pacman -Sl | grep "python " | grep "installed"
mingw64 mingw-w64-x86_64-python 3.8.2-2 [installed]
msys python 3.8.2-1 [installed]
Additional info on each (dependencies, etc.)
$ pacman -Qi mingw-w64-x86_64-python
Name            : mingw-w64-x86_64-python
Version         : 3.8.2-2
Description     : A high-level scripting language (mingw-w64)
Architecture    : any
URL             : https://www.python.org/
Licenses        : PSF
Groups          : None
Provides        : mingw-w64-x86_64-python3=3.8.2
Depends On      : mingw-w64-x86_64-gcc-libs  mingw-w64-x86_64-expat  mingw-w64-x86_64-bzip2  mingw-w64-x86_64-libffi  mingw-w64-x86_64-mpdecimal
                  mingw-w64-x86_64-ncurses  mingw-w64-x86_64-openssl  mingw-w64-x86_64-sqlite3  mingw-w64-x86_64-tcl  mingw-w64-x86_64-tk  mingw-w64-x86_64-zlib
                  mingw-w64-x86_64-xz
Optional Deps   : None
Required By     : mingw-w64-x86_64-gdb  mingw-w64-x86_64-glib2  mingw-w64-x86_64-gtest  mingw-w64-x86_64-mono  mingw-w64-x86_64-postgresql
                  mingw-w64-x86_64-python-apipkg  mingw-w64-x86_64-python-appdirs  mingw-w64-x86_64-python-atomicwrites  mingw-w64-x86_64-python-attrs
                  mingw-w64-x86_64-python-cairo  mingw-w64-x86_64-python-colorama  mingw-w64-x86_64-python-contextlib2  mingw-w64-x86_64-python-cycler
                  mingw-w64-x86_64-python-defusedxml  mingw-w64-x86_64-python-imagesize  mingw-w64-x86_64-python-importlib-metadata  mingw-w64-x86_64-python-iniconfig
                  mingw-w64-x86_64-python-jdcal  mingw-w64-x86_64-python-kiwisolver  mingw-w64-x86_64-python-lxml  mingw-w64-x86_64-python-more-itertools
                  mingw-w64-x86_64-python-numpy  mingw-w64-x86_64-python-olefile  mingw-w64-x86_64-python-ordered-set  mingw-w64-x86_64-python-packaging
                  mingw-w64-x86_64-python-pathlib2  mingw-w64-x86_64-python-pillow  mingw-w64-x86_64-python-pluggy  mingw-w64-x86_64-python-py
                  mingw-w64-x86_64-python-pyparsing  mingw-w64-x86_64-python-pytest  mingw-w64-x86_64-python-pytz  mingw-w64-x86_64-python-scandir
                  mingw-w64-x86_64-python-seaborn  mingw-w64-x86_64-python-setuptools  mingw-w64-x86_64-python-sip  mingw-w64-x86_64-python-six
                  mingw-w64-x86_64-python-wcwidth  mingw-w64-x86_64-python-zipp  mingw-w64-x86_64-vapoursynth
Optional For    : mingw-w64-x86_64-vtk
Conflicts With  : mingw-w64-x86_64-python3  mingw-w64-x86_64-python2<2.7.16-7
Replaces        : mingw-w64-x86_64-python3
Installed Size  : 112.87 MiB
Packager        : Alexey Pavlov <alexpux@gmail.com>
Build Date      : Thu, Apr 9, 2020 10:17:39 AM
Install Date    : Wed, Apr 22, 2020 10:04:36 AM
Install Reason  : Explicitly installed
Install Script  : No
Validated By    : Signature
$ pacman -Qi python
Name            : python
Version         : 3.8.2-1
Description     : Next generation of the python high-level scripting language
Architecture    : i686
URL             : https://www.python.org/
Licenses        : custom
Groups          : None
Provides        : python3
Depends On      : libbz2  libexpat  libffi  liblzma  ncurses  libopenssl  libreadline  mpdecimal  libsqlite  zlib
Optional Deps   : None
Required By     : gdb  python3-appdirs  python3-attrs  python3-pip  python3-pyparsing  python3-six  scons
Optional For    : None
Conflicts With  : None
Replaces        : python3
Installed Size  : 47.27 MiB
Packager        : Alexey Pavlov <alexpux@gmail.com>
Build Date      : Thu, Apr 16, 2020 12:31:48 PM
Install Date    : Wed, Apr 22, 2020 10:15:54 AM
Install Reason  : Explicitly installed
Install Script  : No
Validated By    : Signature
Packages providing python2
$ pacman -Sl | grep "python2 " | grep "installed"
mingw64 mingw-w64-x86_64-python2 2.7.18-1 [installed: 2.7.17-2]
msys python2 2.7.18-1 [installed: 2.7.17-1]
 
     
    