You're not modifying the variable, rather creating a new num1 in the function's namespace. If you want to reference the outer variable you'd need to put global num1 inside of the suma function definition.
>>> num1 = '1'
>>> def suma():
...   num1 = 45345
... 
>>> suma()
>>> num1
'1'
>>> def suma():
...     global num1
...     num1 = 4234
... 
>>> suma()
>>> num1
4234
This answer is the best on SO I've seen around global variables: https://stackoverflow.com/a/423596/5180047
Just realized the comment also answered what I've already said above, whoops! I'll leave this here anyways. Hopefully it's helpful.