An ID in a selector cannot start with a number:
4.1.3 Characters and case
In CSS, identifiers (including element names, classes, and IDs in selectors) can contain only the characters [a-zA-Z0-9] and ISO 10646 characters U+00A0 and higher, plus the hyphen (-) and the underscore (_); they cannot start with a digit, two hyphens, or a hyphen followed by a digit. Identifiers can also contain escaped characters and any ISO 10646 character as a numeric code (see next item). For instance, the identifier "B&W?" may be written as "B\&W\?" or "B\26 W\3F".
You could get around that by writing the selector like this #\31 01, but that is not really recommended (31 is the hexadecimal representation of the character 1):
<style>
     #\31 01{
        width:1em;
        height:1em;
        padding:1em;
        margin: 1em;
        background-color: green;
        color:red;
    }
</style>
<div class="animation" id="animation">hii</div>
<script>
    document.getElementById('animation').id='101';
</script>
 
 
So it is better to prefix the ID with some letters.