Most simple way is to use a file lock. Lock some file when script if started and release the lock at the end. If the lock cannot be obtained, then another script is running:
<?php
  define("LOCK_FILE_NAME", dirname(__FILE__) . DIRECTORY_SEPARATOR . "lock.lck"); // path and filename of the lock file
  $flockfile = fopen(LOCK_FILE_NAME, 'c');
  if (!flock($flockfile, LOCK_EX | LOCK_NB)) { // try to lock file exclusive, without blocking
    fclose($flockfile); // If no luck - exist
    $flockfile = NULL;
    die('Another process is running');
  }
  print("Lock obtained" . PHP_EOL);
  register_shutdown_function(
    function() use (&$flockfile) {
      if (isset($flockfile)) {
        flock($flockfile, LOCK_UN);  // Release the lock on shutdown
        fclose($flockfile);
        $flockfile = NULL;
        print("Lock released" . PHP_EOL);
      }
    }
  );
  sleep(5); // Emulate some work