400,000 strings is absolutely trivial.
Just put them in a dictionary (list, whatever is relevant and that you prefer).
It's a total non-issue.
It's likely you would just load them from a text file, easy as pie.
public TextAsset theTextFile;
(Just drag to the link in the Inspector, like any texture or similar.)
you can then very easily read that file as, say, JSON. (Just use JsonUtility. You can find numerous examples of this in SO and elsewhere.) For example,
Blah bb = JsonUtility.FromJson< Blah >(ta.text);
yourDict = bb.fieldname.ToDictionary(i => i.tag, i => i);
Note that you mention "memory" and so on. It's totally irrelevant, the data you are talking about is the fraction of the size of any tiny image - ! , it's a non-issue, you don't have to think about it. The hardware/software system will handle it.
P.S. ...
If you literally want to use csv, it's totally easy. I suggest you ask a new question giving the details of your file and so on, so you can get an exact answer.
Note that you'd just use a HashSet rather than a Dictionary. It's even easier.
It's just something like:
var wordList = theTextFile.text.Split('\n');
You can google many examples!
https://stackoverflow.com/a/9791488/294884
http://answers.unity.com/answers/397537/view.html