I think you need to re-evaluate Carlos' answer.
See the section Implementing COM Objects with Python in Mark Hammond's book Python Programming on Win32. 
You should be able to create a COM object, then have .Net interact with it. 
From the book the following will create a COM server with a single method.
# SimpleCOMServer.py - A sample COM server - almost as small as they come!
# 
# We expose a single method in a Python COM object.
class PythonUtilities:
    _public_methods_ = [ 'SplitString' ]
    _reg_progid_ = "PythonDemos.Utilities"
    # NEVER copy the following ID 
    # Use "print pythoncom.CreateGuid()" to make a new one.
    _reg_clsid_ = "{41E24E95-D45A-11D2-852C-204C4F4F5020}"
    def SplitString(self, val, item=None):
        import string
        if item != None: item = str(item)
        return string.split(str(val), item)
# Add code so that when this script is run by
# Python.exe, it self-registers.
if __name__=='__main__':
    print "Registering COM server..."
    import win32com.server.register
    win32com.server.register.UseCommandLine(PythonUtilities)
The book goes on to say ".. you can do this by executing the code as a normal Python script. The easiest way to do this is to open the source file in PythonWin and use the Run command from the File menu. "
I think you need the ActivePython distribution from Activestate to do it.
See this question Consuming Python COM Server from .NET