Just add a handler for the keydown event and set e.handled=true for key you don't want to allow.   The sample is on the page and handle alt-p and alt-n but same principle.   You are going to need to modify this code as it was not designed to cancel a key stroke but it does show how to handle the keydown event.
    <Window x:Class="Gabe2a.MainWindow"
    xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
    xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
    xmlns:diag="clr-namespace:System.Diagnostics;assembly=WindowsBase"
    DataContext="{Binding Source={x:Static Application.Current}}"
    Title="Gabriel Main" Height="600" Width="800" KeyDown="Window_KeyDown">
    private void Window_KeyDown(object sender, KeyEventArgs e)
    {
        // Debug.WriteLine("Main Window Window_KeyDown " + e.Key.ToString());
        e.Handled = false;
        if (e.KeyboardDevice.Modifiers == ModifierKeys.Alt) //  && e.KeyboardDevice.IsKeyDown(Key.RightAlt))
        {
            if (e.Key == Key.System && e.SystemKey == Key.N)
            {
                e.Handled = true;
                App.StaticGabeLib.Search.NextDoc();
            }
            else if (e.Key == Key.System && e.SystemKey == Key.P)
            {
                e.Handled = true;
                App.StaticGabeLib.Search.PriorDoc();
            }
        }
        base.OnKeyDown(e);
    }
Sample for attaching the KeyDown to a TextBox
            <TextBox KeyDown="TBKeydown" />