Generate the dataframe:
import pandas as pd
df = pd.DataFrame({
    "0": [True, True, True, True, True],
    "1": [False, False, False, False, False],
    "2": [False, False, False, False, False],
    "3": [False, False, False, False, False],
    "4": [False, True, False, False, False]
})
Get the number of true per row:
df = df.assign(number_of_true= lambda x: x.sum(axis=1))
      0      1      2      3      4  number_of_true
0  True  False  False  False  False               1
1  True  False  False  False   True               2
2  True  False  False  False  False               1
3  True  False  False  False  False               1
4  True  False  False  False  False               1
Select row that do not have two True on one row:
df = df.query("number_of_true != 2")
One liner:
(
df
.assign(number_of_true= lambda x: x.sum(axis=1))
.query("number_of_true != 2")
.drop(columns="number_of_true") #clean dataframe
)
Output:
      0      1      2      3      4
0  True  False  False  False  False
2  True  False  False  False  False
3  True  False  False  False  False
4  True  False  False  False  False