You can get a random index using
let i = Math.floor(Math.random() * array.length),
then you should remove the elment from the array maybe using
arr.splice(i ,1).
This could be a sample:
let arr = [1,2,3,4,5];
for(let n in arr)
  removeRandom(arr);
function removeRandom(arr){
  let i = Math.floor(Math.random() * arr.length);
  let str= "pre "
  for(let n in arr)
   str += arr[n] ;
  
  console.log("str "+str)
  console.log("arr[i] " + arr[i]);
  arr.splice(i ,1);
 
  str= "post "
  for(let n in arr)
   str += arr[n] ;
  
  console.log("str "+str)
}