Using grid it's pretty trivial.
Your layout is basically a two rows and 3 columns layout.
Both rows take 50% of the height or in fraction 1fr, while for first column takes 50% of the width and the others 25% or in fraction: 2fr, 1fr and 1fr.
The first image spans across the two rows.
ul {
  list-style: none;
  display: grid;
  grid-template-columns: 2fr 1fr 1fr;
  grid-template-rows: 1fr 1fr;
}
li:first-child {
  grid-row: span 2;
}
If you want a gap, you can add it to the grid:
  gap: 1rem;
To have the pictures fill their cells:
img {
  display: block;
  width: 100%;
  height: 100%;
  object-fit: cover;
}
Snippet:
* {
  margin: 0px;
  padding: 0px;
}
ul {
  list-style: none;
  display: grid;
  grid-template-columns: 2fr 1fr 1fr;
  grid-template-rows: 1fr 1fr;
  gap: 1rem;
}
li:first-child {
  grid-row: span 2;
}
img {
  display: block;
  width: 100%;
  height: 100%;
  object-fit: cover;
}
<ul>
  <li>
    <img src="https://via.placeholder.com/400" />
  </li>
  <li>
    <img src="https://via.placeholder.com/400" />
  </li>
  <li>
    <img src="https://via.placeholder.com/400" />
  </li>
  <li>
    <img src="https://via.placeholder.com/400" />
  </li>
  <li>
    <img src="https://via.placeholder.com/400" />
  </li>
</ul>