You can extend EditTextPreference to get control over the click handler.
package myPackage;
public class CustomEditTextPreference extends EditTextPreference {
    public CustomEditTextPreference(Context context) {
        super(context);
    }
    public CustomEditTextPreference(Context context, AttributeSet attrs) {
        super(context, attrs);
    }
    public CustomEditTextPreference(Context context, AttributeSet attrs, int defStyle) {
        super(context, attrs, defStyle);
    }
    @Override
    public void onClick(DialogInterface dialog, int which) {
        if (which == DialogInterface.BUTTON_POSITIVE) {
            // add Handler here
        }
        super.onClick(dialog, which);
    }
}
In the Xml instead of <EditTextPreference/> reference it like this:
<myPackage.CustomEditTextPreference android:dialogTitle="Registration Key" android:key="challengeKey" android:title="Registration Key" android:summary="Click here to enter the registration key you received by email."/>