This answer isn't as clean as using itertools but the ideas could be useful.
Drawing inspiration from the construction of zip() here, we could do the following.
>>> a = iter([[1,2,3],[4,5,6],[7,8,9,10]])
>>> sentinel = object()
>>> result = [[]]
>>> while True:
>>> l = next(a,sentinel)
>>> if l == sentinel:
>>> break
>>> result = [ r + [digit] for r in result for digit in l]
>>> print(result)
[[1, 4, 7], [1, 4, 8], [1, 4, 9], [1, 4, 10], [1, 5, 7], [1, 5, 8], [1, 5, 9], [1, 5, 10], [1, 6, 7], [1, 6, 8], [1, 6, 9], [1, 6, 10], [2, 4, 7], [2, 4, 8], [2, 4, 9], [2, 4, 10], [2, 5, 7], [2, 5, 8], [2, 5, 9], [2, 5, 10], [2, 6, 7], [2, 6, 8], [2, 6, 9], [2, 6, 10], [3, 4, 7], [3, 4, 8], [3, 4, 9], [3, 4, 10], [3, 5, 7], [3, 5, 8], [3, 5, 9], [3, 5, 10], [3, 6, 7], [3, 6, 8], [3, 6, 9], [3, 6, 10]]
We use a as an iterator in order to successively get the next item of it without needing to know how many there are a priori. The next command will output sentinel (which is an object created solely to make this comparison, see here for some explanation) when we run out of lists in a, causing the if statement to trigger so we break out of the loop.