Each serial device shows up twice in /dev, once as a tty.* and once as a cu.*.
What is the cu.* device? How does it differ from the tty.* device?
ls -l /dev/*.usbmodem621
Output:
crw-rw-rw- 1 root wheel 11, 5 Dec 25 18:00 /dev/cu.usbmodem621
crw-rw-rw- 1 root wheel 11, 4 Dec 25 18:00 /dev/tty.usbmodem621