Currently I'm setting my client connection for node-mysql by doing the following in my app.js and a special config/environment.js:
var client = mysql.createClient({
  user:     'USER',
  database: 'DATABASE',
  password: 'PASSWORD',
  host:     'HOST'
});
app.configure(function(){
  ...
  app.set('client', client);
  ...
});
Then in my client code I just call app.settings.client to use the MySQL client.
I'm not sure if this is the right approach, and it certainly doesn't work when I'm doing testing, as I need a running instance of the app.
Any suggestions?