Edit: Looks like my colleagues had some fun. False alarm.
My work computer is running OSX Yosemite 10.10.1. I noticed my keyboard layout was changed to Dvorak and my mouse direction reversed when logging into my work computer this morning. The computer is always locked when I leave the office. To me, it does not seem possible to add keyboards layouts or change these settings from the lock-screen.
Furthermore I found the same commands ran as in this post. There are however nothing else in root's bash history, even though I use the root account once in a while. Also, /var/log/secure.log does not exist in the filesystem.
I'm not a Unix expert by any sense. What other steps can I take to find out if anything was done to my computer? I don't like this situation.