Disconnect and close serial port from console so I can use it in my application

Question

Ubuntu 16.04

I need /dev/ttyS0 (serial port) for use in my application.

Command:

~$ dmesg | grep tty

Response with:

[    0.000000] console [tty0] enabled
[    0.691609] 00:05: ttyS0 at I/O 0x3f8 (irq = 4, base_baud = 115200) is a 16550A
[    0.715333] 00:06: ttyS1 at I/O 0x2f8 (irq = 3, base_baud = 115200) is a 16550A

How do I close the serial port (for current session only is also ok) so I can use it for my own needs?