You can disable a device in Device Manager without uninstalling the drivers. Simply right-click the device > properties > disable.
I use this method on a number of laptops.
Some also come with touch-pad managers that have access to disable the keyboard when another is present. I do that with my mouse and touch-pad. Whenever I have my Bluetooth mouse plugged in the touch-pad gets disabled.
I use a Dell Latitude and have Windows 7 Enterprise. Your experience might depend on what device manufacture and what hardware configuration software is available. The Device Manager option is fairly straight forward.