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I noticed that after some programs are uninstalled, they leave empty folders in c:\windows\assembly\ (Windows 7).

Although there is no harm in keeping these folders, I want to keep things tidy and clean out unused junk.

Is is safe to delete these empty folders?

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C:\Windows\Assembly folder is the Global Assembly Cache (GAC) used by .NET Run time.

Generally, it is advisable to use the .NET command gacutil ( https://docs.microsoft.com/en-us/dotnet/framework/tools/gacutil-exe-gac-tool) to manage the contents of this folder.

However, if you think, it has any empty folder, you can delete that. If you delete any non-empty folder, it might create the problem to run .NET based program on your machine.

Please note, you will need administrator rights to delete any content in this folder (even if its an empty folder).

SiriA
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