So here are some details that matter and that I know about. Of course, if there are any encryption keys installed on the freshly manufactured piece of ROM, then I will not be able to get them back, which, if we are talking about PCs, will have the consequences of Windows not being able to boot in secure mode, (maybe some popular Linux distros like Ubuntu or Fedora will not boot either as they rely of signatures from Microsoft?). But if after flashing, say, coreboot, into the ROM, along with TianoCore, I am able to run any operating system that will be compatible with this firmware, then how can I "brick" my laptop? I have seen a lot of folks talking about bricking their Chomebooks, but in the end, they can just flash anything into the ROM, then in case something went wrong, flash it again, so why does this notion of a bricked laptop even exist?
And yes, I understand that it may be physically difficult to do the flashing (due to embedded controllers, for example, as this page suggests https://www.flashrom.org/Laptops), but if you want to answer, please suppose we are able to flash (as is the case with Chromebooks, as far as I know)
Edit: by ROM I mean erasable and programmable non-volatile memory, in particular flash.