Is it possible in Windows 10 home (maybe through group policies?) to restrict or outright block specific applications from ever accessing specific physical drives?
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(Which version of Windows?)
In the general case, you will need to run the application under a specific user account and limit its access to the root folder of the disk(s).
For more information see this Microsoft article : Access Control Overview.
On Windows Server you may use Group Policies.
See the article
How to Assign Permissions to Files and Folders through Group Policy.
harrymc
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