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On my new Windows 10 PC Sophos antivirus is preinstaled defenetly not the best antivirus programm, but since I have no other have to live with it. The bigest problem with it is the deletion of files which it thinks to be malicious without even asking me. Is there a way to temporally deactivate antivirus? I tried to shut it down with task manager, but that´s not working. I have also instaled Malwarebytes which could replace Sophos, but it was not working. Looks like Malwarebytes is not compatible with Windows 10, since had exactly the same problem on some other Windows 10 PC.

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With Windows 10 (and 11) you definitely have options.

Windows Defender Anti Virus is built right into Windows 10 and is very good by itself. I rely on Windows Defender myself.

If you need to, you can whitelist Apps and Files if WD thinks they are harmful (common to all AV).

Uninstall Sophos and then Windows Defender will take over.

You should be able to uninstall Sophos in Programs and Features. Look also on the Sophos site for a complete uninstall App.

It is very difficult to temporarily stop any real time AV, so the best thing you can do is whitelist apps and files causing issues.

AV Apps including WD are hooked right into Windows core programs.

If you feel you wish to retain Sophos, make sure you whitelist any Apps or Files that are causing issues in Sophos.