I am using Outlook 2007 on Windows XP for work, and always hit Ctrl+Shift+D to send messages. That's the shortcut in Mail.app and in MobileMe's Mail web app, and I prefer it to Ctrl+Enter, which is Outlook's send mail shortcut. Spoiled by Mac OS X's ability to easily change shortcuts for any application, I've been looking for a way to change the shortcut. How can you do this?
Update
I ended up using TeX HeX's suggestion, AutoHotkey. The script I wrote is below:
; Remap Ctrl+Shift+D to Ctrl+Enter for Outlook in Message window
#IfWinActive, ahk_class rctrl_renwnd32
^+d::
Send ^{enter}
return