I suggest you use AutohotKey for this. You then can try to
- Listen for MouseWheel Event in either Application (Reader, Safari)
- Switch focus to the other application, Send Mousewheel Event
- Switch back
I Hope this is fast enough to appear "seemless"
[EDIT]
Here is the script I have made following this answer :
WheelDown::
SetTitleMatchMode, 2
IfWinActive, SafariTitle ; Replace 'SafariTitle' by the title of the safari windows
{
CoordMode, Mouse, Screen
WinGet, active_id, ID, A
IfWinExist, Adobe
{
Send {WheelDown}
WinActivate ; Automatically uses the window found above.
Send {WheelDown}
Send {WheelDown}
WinActivate, ahk_id %active_id%
}
}
Else
{
Send {WheelDown}
}
return
WheelUp::
SetTitleMatchMode, 2
IfWinActive, SafariTitle ; Replace 'SafariTitle' by the title of the safari windows
{
CoordMode, Mouse, Screen
WinGet, active_id, ID, A
IfWinExist, Adobe
{
Send {WheelUp}
WinActivate ; Automatically uses the window found above.
Send {WheelUp}
Send {WheelUp}
WinActivate, ahk_id %active_id%
}
}
Else
{
Send {WheelUp}
}
return