Occasionally, I have an issue where the mouse hotspot will be about 10-20px off. For example, mouseovers and clicks will be detected to one side of where the cursor appears to be pointing.
I have a multi-monitor system consisting of an eyefinity-6 array and three additional monitors. This only occurs on one screen. Not a specific one, but one at a time. It comes and goes. I've gone through several video cards, all ATI, and this has happened on and off throughout the years.
A cold boot corrects the problem.
What could cause this?