local / project-specific configuration
If it's okay to configure the specific commands / local exceptions centrally, you can put such autocmds into your ~/.vimrc:
:autocmd BufRead,BufNewFile /path/to/dir/* setlocal ts=4 sw=4
It is important to use :setlocal instead of :set, and likewise :map <buffer> ... and :command! -buffer ....
On the other hand, if you want the specific configuration stored with the project (and don't want to embed this in all files via modelines), you have the following two options:
Local config with built-in functionality
If you always start Vim from the project root directory, the built-in
:set exrc
enables the reading of a .vimrc file from the current directory. You can place the :set ts=4 sw=4 commands in there.
Local config through plugin
Otherwise, you need the help of a plugin; there are several on vim.org; I can recommend the localrc plugin (especially with my own enhancements), which even allows local filetype-specific configuration.
Note that reading configuration from the file system has security implications; you may want to :set secure.