I had a similar problem with Microsoft Office files. If I opened Microsoft Word, for example, and then Ctrl-O to open a file, it would work instantly. However, if I double clicked on a file, it took a very long time to open. I found this issue somewhere on the forums, saying that this was a DDE problem. I went ahead and fixed it.
However later I also discovered this problem.
If I double click on my computer it starts fine, However, if I use the shortcut keys (Win+E) it takes forever.
Is there a quick fix for this I could try?
Is there a bigger underlying problem causing this?