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You can use CleanHandlers:

It works on Vista and 7 as well. If you wish to manually remove the registry entries, they are located in the following locations:
HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Explorer\AutoplayHandlers\Handlers\<handler>
HKEY_LOCAL_MACHINE\Software\Microsoft\Windows\CurrentVersion\Explorer\AutoplayHandlers\EventHandlers\<Event Name></pre>
Gareth
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