systemic

From system +‎ -ic. Doublet of systematic.

• (Received Pronunciation) IPA^(key): /sɪˈstɛmɪk/, /sɪˈstiːmɪk/
• (General American, Canada) IPA^(key): /sɪˈstɛmɪk/

  • Audio (US):

    (file)

• (General Australian) IPA^(key): /sɪˈstemɪk/
• Rhymes: -ɛmɪk, -iːmɪk

systemic (not comparable)

1. Embedded within and spread throughout and affecting a whole system, group, body, economy, market, or society.
   • 2022 August 10, Dr Mike Esbester, “New understandings from old incidents”, in RAIL, number 963, page 59:

     We can learn from the incidents found it the project database - looking at them and understanding what happened and what might have been done differently. We can see past errors, including systemic issues that required attention at managerial levels.

2. (physiology) Pertaining to an entire organism.

   Synonym: holistic

   • 2022 March 17, Joan T. Merrill, Victoria P. Werth, Richard Furie et al., “Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus”, in The New England Journal of Medicine, volume 386, number 11, →DOI, page 1034:

     Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).

Not to be confused with systematic (“methodical”).

• topical
• (antonym(s) of “widespread, prevalent”): endemic

• embedded